Comparative Analysis of Different Brands of Ibuprofen available on the Georgian Pharmaceutical Market
DOI:
https://doi.org/10.56580/GEOMEDI34Keywords:
Ibuprofen, Georgia, Spectrophotometry, Generic drug, Active Pharmaceutical IngredientAbstract
According to the World Health Organization (WHO), 1 out of 10 medical products in developing countries are substandard or falsified. Since Georgia is a developing country and is listed among the countries where substandard and falsified medical products have been discovered and reported to WHO, it is important to explore the quality of medical products available on the Georgian pharmaceutical market. As an initial study, we have chosen one of the most widely used drugs worldwide – ibuprofen, available in the pharmacy network in Tbilisi – the capital of Georgia. We have studied 10 different brands, imported and locally produced, and 2 brand-name ibuprofens (Motrin and Advil). The content of the Active Pharmaceutical Ingredient (API) was determined by a spectrophotometer, in the ultraviolet region. The obtained results showed that all brand ibuprofens contained labeled amounts of API.
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References
Ten years in public health, 2007–2017: report by Dr Margaret Chan, Director-General, World Health Organization. Geneva: World Health Organization; 2017. Licence: CC BY-NC-SA 3.0 IGO. Available: https://apps.who.int/iris/bitstream/handle/10665/255355/9789241512442-eng.pdf
White CM. Generic Drugs Not as Safe as FDA Wants You to Believe. Ann Pharmacother. 2020;54: 283–286. doi:10.1177/10600280198816923.
WHO Global Surveillance and Monitoring System for substandard and falsified medical products. Geneva: World Health Organization; 2017, Licence: CC BY-NC-SA 3.0 IGO; Available: https://apps.who.int/iris/bitstream/handle/10665/326708/9789241513425-eng.pdf
Ozawa S, Evans DR, Bessias S, Haynie DG, Yemeke TT, Laing SK, et al. Prevalence and Estimated Economic Burden of Substandard and Falsified Medicines in Low- and Middle-Income Countries: A Systematic Review and Meta-analysis. JAMA Netw Open. 2018;1: e181662. doi:10.1001/jamanetworkopen.2018.1662
Almuzaini T, Choonara I, Sammons H. Substandard and counterfeit medicines: a systematic review of the literature. BMJ Open. 2013;3: e002923. doi:10.1136/bmjopen-2013-002923
McManus D, Naughton BD. A systematic review of substandard, falsified, unlicensed and unregistered medicine sampling studies: a focus on context, prevalence, and quality. BMJ Glob Health. 2020;5: e002393. doi:10.1136/bmjgh-2020-002393
Fang L, Karakiulakis G, Roth M. Are patients with hypertension and diabetes mellitus at increased risk for COVID-19 infection? Lancet Respir Med. 2020;8: e21. doi:10.1016/S2213-2600(20)30116-8
Moore N, Bosco-Levy P, Thurin N, Blin P, Droz-Perroteau C. NSAIDs and COVID-19: A Systematic Review and Meta-analysis. Drug Saf. 2021;44: 929–938. doi:10.1007/s40264-021-01089-5
Rinott E, Kozer E, Shapira Y, Bar-Haim A, Youngster I. Ibuprofen use and clinical outcomes in COVID-19 patients. Clin Microbiol Infect Off Publ Eur Soc Clin Microbiol Infect Dis. 2020;26: 1259.e5-1259.e7. doi:10.1016/j.cmi.2020.06.003
Hauk C, Hagen N, Heide L. Identification of Substandard and Falsified Medicines: Influence of Different Tolerance Limits and Use of Authenticity Inquiries. Am J Trop Med Hyg. 2021;104: 1936–1945. doi:10.4269/ajtmh.20-1612
Khurelbat D, Dorj G, Sunderland B, Sanjjav T, Bayarsaikhan E, Damdinjav D, et al. A cross-sectional analysis of falsified, counterfeit and substandard medicines in a low-middle income country. BMC Public Health. 2020;20: 743. doi:10.1186/s12889-020-08897-x
Riddhi Gondalia, Rajashree Mashru, Pankaj Savaliya. Development and Validation of Spectrophotometric Methods for Simultaneous Estimation of IBUPROFEN and PARACETAMOL in Soft gelatin capsule by Simultaneous Equation Method. Int J ChemTech Res. 2010;2: 1881–1885.
Kedar Tejashree, R., P. Jadhav Ankush, J. Kore Kakasaheb, and T. Jadhav Ravindra. Development and validation of UV-Spectrophotometric methods for simultaneous estimation of Paracetamol and Ibuprofen in bulk and tablet dosage form." (2020). 2020;5. Available: https://ijrti.org/papers/IJRTI2005019.pdf
Eraga SO, Arhewoh MI, Chibuogwu RN, Iwuagwu MA. A comparative UV− HPLC analysis of ten brands of ibuprofen tablets. Asian Pac J Trop Biomed. 2015;5: 880–884. doi:10.1016/j.apjtb.2015.06.005
Lawson G, Ogwu J, Tanna S. Quantitative screening of the pharmaceutical ingredient for the rapid identification of substandard and falsified medicines using reflectance infrared spectroscopy. PloS One. 2018;13: e0202059. doi:10.1371/journal.pone.0202059
Nayyar GML, Attaran A, Clark JP, Culzoni MJ, Fernandez FM, Herrington JE, et al. Responding to the pandemic of falsified medicines. Am J Trop Med Hyg. 2015;92:113–118. doi:10.4269/ajtmh.14-0393
