Changes in Indicators of Biochemical Homeostasis in Patients With Moderate SARS-CoV-2

Authors

  • Anna Khoroshikh Voronezh State Medical University named after N.N. Burdenko, Voronezh, 394036, Russian Federation Author
  • Marina Pirtskhalava Teaching University Geomedi, Tbilisi, 0114, Georgia Author
  • Valentina Mittova Scientific-Research Institute of Experimental and Clinical Medicine, Teaching University Geomedi, Tbilisi, 0114, Georgia Author
  • Yana Arzhanykh Voronezh State Medical University named after N.N. Burdenko, Voronezh, 394036, Russian Federation Author
  • Galina Batishcheva Voronezh State Medical University named after N.N. Burdenko, Voronezh, 394036, Russian Federation Author
  • Viktoriya Shishkina Voronezh State Medical University named after N.N. Burdenko, Voronezh, 394036, Russian Federation Author
  • Oleg Zolotukhin Voronezh State Medical University named after N.N. Burdenko, Voronezh, 394036, Russian Federation Author
  • Nataliya Khoroshikh Voronezh State Medical University named after N.N. Burdenko, Voronezh, 394036, Russian Federation Author
  • Malkhaz Vakhania Scientific-Research Institute of Experimental and Clinical Medicine, Teaching University Geomedi, Tbilisi, 0114, Georgia Author

DOI:

https://doi.org/10.56580/GEOMEDI36

Keywords:

SARS-CoV-2, ACE2, biochemical homeostasis, type 2 diabetes mellitus, hemostasis, pharmacotherapy

Abstract

This article demonstrates changes in biochemical homeostasis in patients with moderate SARS-CoV-2 and type 2 diabetes mellitus (T2DM) or hyperglycemia identified for the first time. The results of the study were estimated according to the indicators of a biochemical blood test in the acute phase and the convalescent phase of the SARS-CoV-2. The most significant deviations of homeostasis were observed in patients with T2DM. The development and worsening of hyperglycemia were due to the specific effect of the virus on carbohydrate metabolism mediated via ACE2 receptors located in hepatocytes and pancreatic cells. The development of hyperglycemia in SARS-CoV-2 patients was not associated with the use of drugs with hyperglycemic effects in particular glucocorticoids. The obtained data indicate the blood coagulation system’s activation and the severity of this activation depended on the severity of SARS-CoV-2 and somatic complications.

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Published

2023-12-29

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Articles

How to Cite

1.
Khoroshikh A, Pirtskhalava M, Mittova V, et al. Changes in Indicators of Biochemical Homeostasis in Patients With Moderate SARS-CoV-2. MIMM. 2023;26(2):49-57. doi:10.56580/GEOMEDI36