Changes in Indicators of Biochemical Homeostasis in Patients With Moderate SARS-CoV-2
DOI:
https://doi.org/10.56580/GEOMEDI36Keywords:
SARS-CoV-2, ACE2, biochemical homeostasis, type 2 diabetes mellitus, hemostasis, pharmacotherapyAbstract
This article demonstrates changes in biochemical homeostasis in patients with moderate SARS-CoV-2 and type 2 diabetes mellitus (T2DM) or hyperglycemia identified for the first time. The results of the study were estimated according to the indicators of a biochemical blood test in the acute phase and the convalescent phase of the SARS-CoV-2. The most significant deviations of homeostasis were observed in patients with T2DM. The development and worsening of hyperglycemia were due to the specific effect of the virus on carbohydrate metabolism mediated via ACE2 receptors located in hepatocytes and pancreatic cells. The development of hyperglycemia in SARS-CoV-2 patients was not associated with the use of drugs with hyperglycemic effects in particular glucocorticoids. The obtained data indicate the blood coagulation system’s activation and the severity of this activation depended on the severity of SARS-CoV-2 and somatic complications.
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