Hepatoprotective effect of protein extract of the Potamogeton perfoliatus L. against carbon-tetrachloride (CCI4) - induced hepatic injury in mice

Authors

  • Marina Pirtskhalava Teaching University Geomedi, Tbilisi, 0114, Georgia Author https://orcid.org/0000-0002-0464-1345
  • Malkhaz Vakhania Scientific-Research Institute of Experimental and Clinical Medicine, Teaching University Geomedi, Tbilisi, 0114, Georgia Author
  • Teimuraz Tavkhelidze Teaching University Geomedi, Tbilisi, 0114, Georgia Author https://orcid.org/0009-0005-9618-3861
  • Marina Gogodze Scientific-Research Institute of Experimental and Clinical Medicine, Teaching University Geomedi, Tbilisi, 0114, Georgia Author
  • Tornike Mindiashvili Scientific-Research Institute of Experimental and Clinical Medicine, Teaching University Geomedi, Tbilisi, 0114, Georgia Author
  • Mariam Kobiashvili Scientific-Research Institute of Experimental and Clinical Medicine, Teaching University Geomedi, Tbilisi, 0114, Georgia Author
  • Valentina Mittova Scientific-Research Institute of Experimental and Clinical Medicine, Teaching University Geomedi, Tbilisi, 0114, Georgia Author

DOI:

https://doi.org/10.56580/GEOMEDI33

Keywords:

Potamogeton perfoliatus L., proteins, tetrachloromethane, CCl4, chromatography, gel filtration, hepatocytes, SDS-PAGE

Abstract

This article demonstrates the hepatoprotective action of the protein extract of the aquatic plant Potamogeton perfoliatus L. based on the histopathologic changes in the liver of mice with CCl4-induced liver damage. Using the chromatography, 4 fractions of the protein extract were obtained. It has been suggested that a fourth fraction corresponding to low molecular weight protein should most likely exhibit hepatoprotective properties. SDS-PAGE of P. perfoliatus L. revealed a protein with molecular weight of 21 kDa corresponding to the fourth peak of a chromatogram.

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References

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Published

2023-12-29

Issue

Vol. 26 No. 2 (2023)

Section

Articles

How to Cite

1.
Pirtskhalava M, Vakhania M, Tavkhelidze T, et al. Hepatoprotective effect of protein extract of the Potamogeton perfoliatus L. against carbon-tetrachloride (CCI4) - induced hepatic injury in mice. MIMM. 2023;26(2):30-39. doi:10.56580/GEOMEDI33

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