The impact of the Coronavirus (COVID-19) on the menstrual cycle and mental health of young Georgian women

Authors

  • Elene Asanidze Teaching University Geomedi, Tbilisi, 0114, Georgia Author https://orcid.org/0000-0002-8779-7731
  • Jenaro Kristesashvili Ivane Javakhishvili Tbilisi State University, Tbilisi, 0179, Georgia Author
  • Nunu Tchagiashvili Samtskhe-Javakheti State University, Akhaltsikhe, 0800, Georgia Author
  • Tamar Kakhniashvili Ivane Javakhishvili Tbilisi State University, Tbilisi, 0179, Georgia Author
  • Aleksandre Asanidze Tbilisi State Medical University, Tbilisi, 0186, Georgia Author

DOI:

https://doi.org/10.56580/GEOMEDI22

Keywords:

COVID-19, coronavirus infection, menstrual cycle, depression, stress

Abstract

The Coronavirus (COVID19) damages various systems and organs and can directly affect the reproductive system. Coronavirus infection affects not only physical health but also causes a significant threat to mental health.

Objective of the study was to investigate the impact of the coronavirus infection and vaccination against coronavirus infection on the menstrual cycle and mental health of young Georgian women and establish the relationship between them.

Methods: A cross-sectional study was conducted by administering online questionnaires to young women (18-25 years) in Georgia. Through questionnaires, we determined the characteristics of the menstrual cycle, the psychological state of the participants before being infected with the coronavirus, in the period 3-6 months after the infection and after the vaccination against the coronavirus infection.

Results: 48.2 % of participants reported significant changes in their menstrual cycle after the coronavirus infection. Participants' mean menstrual cycle length significantly increased after 3 months of coronavirus infection, p<0.05. Participants' mean menstrual cycle length before, and 6 months after the coronavirus infection did not differ significantly. Duration of menstruation before the pandemic was significantly shorter than after 3 and 6 months of infection, p<0.05. The prevalence of premenstrual symptoms components and dysmenorrhea was significantly increased after 3 and 6 months of the coronavirus infection, p<0.05.

Changes in the menstrual cycle within 3 months after vaccination were found in 58.8% of cases, the severity of which significantly decreased 6 months after vaccination, p<0.001. Women noted a significant increase in low mood, poor concentration, anxiety, poor sleep, loneliness after COVID-19 and vaccination, p<0.05

Conclusions:  Coronavirus infection causes significant changes of the menstrual cycle and mental health in Georgian young women. The study indicated a link between the COVID-19 pandemic-induced anxiety, stress, depression, and menstrual cycle irregularity.

Metrics

Metrics Loading ...

References

Joshee S., Vatti N., Chang C. Long-Term Effects of COVID-19. Mayo Clin Proc. 2022 Mar; 97(3): 579-599.

Aolymat I, Khasawneh AI, Al-Tamimi M. COVID-19-Associated Mental Health Impact on Menstrual Function Aspects: Dysmenorrhea and Premenstrual Syndrome, and Genitourinary Tract Health: A Cross Sectional Study among Jordanian Medical Students. Int J Environ Res Public Health. 2022 Jan 27; 19(3): 1439.

Italia L, Tomasoni D., Bisegna S. at all. COVID-19 and Heart Failure: From Epidemiology During the Pandemic to Myocardial Injury, Myocarditis, and Heart Failure Sequelae. Front Cardiovasc Med. 2021 Aug 10; 8: 713560

Della Gatta AN., Rizzo R., Pilu G. at all Coronavirus disease 2019 during pregnancy: a systematic review of reported cases. Am J Obstet Gynecol. 2020 Jul; 223(1): 36-41.

Demir O, Sal H, Comba C. Triangle of COVID, anxiety and menstrual cycle. J Obstet Gynaecol. 2021 Nov; 41(8): 1257-1261.

Toufexis D., Rivarola MA., Lara H. at all. Stress and the reproductive axis. J Neuroendocrinol. 2014 Sep; 26(9): 573-86

Tikellis C, Bernardi S, Burns WC Angiotensin-converting enzyme 2 is a key modulator of the renin-angiotensin system in cardiovascular and renal disease. Curr Opin Nephrol Hypertens. 2011 Jan; 20(1):62-8.

Beyerstedt S, Casaro EB, Rangel ÉB. COVID-19: angiotensin-converting enzyme 2 (ACE2) expression and tissue susceptibility to SARS-CoV-2 infection. Eur J Clin Microbiol Infect Dis. 2021; 40(5): 905-919

Li W, Moore MJ, Vasilieva N, Sui J. at al. Somasundaran M, Sullivan JL, Luzuriaga K, Greenough TC, Choe H, Farzan M. Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus. Nature. 2003; 426: 450–454.

Chadchan SB, Popli P, Maurya VK. At all. The SARS-CoV-2 receptor, angiotensin-converting enzyme 2, is required for human endometrial stromal cell decidualization. Biol Reprod. 2021 Feb 11; 104(2): 336-343. D

Samuels, M.L., Witmer, J.A. and Schaffner, A., Statistics for the life sciences. Pearson education. 2012.

Bacchieri, A. and Della Cioppa, G., Fundamentals of clinical research: bridging medicine, statistics, and operations. Springer Science & Business Media. 2007.

Laksham KB, Selvaraj R, Kar SS. Menstrual disorders, and quality of life of women in an urban area of Puducherry: A community-based cross-sectional study. J Family Med Prim Care. 2019 Jan; 8(1): 137-140.

Saei Ghare Naz M, Rostami Dovom M, Ramezani Tehrani F. The Menstrual Disturbances in Endocrine Disorders: A Narrative Review. Int J Endocrinol Metab. 2020 Oct 14; 18(4).

Al-Najjar MAA, Al-Alwany RR, Al-Rshoud FM. At all Menstrual changes following COVID-19 infection: A cross-sectional study from Jordan and Iraq. PLoS One. 2022 Jun 29; 17(6).

Lebar V, Laganà AS, Chiantera V. at all The Effect of COVID-19 on the Menstrual Cycle: A Systematic Review. J Clin Med. 2022 Jun 30; 11(13): 3800.

Tayyaba Rehan S, Imran L, Mansoor H. at all. Effects of SARS-CoV-2 infection and COVID-19 pandemic on menstrual health of women: A systematic review. Health Sci Rep. 2022 Oct 8; 5(6)

Ozimek N., Velez K., Anvari H. at all Impact of stress on menstrual cyclicity during the coronavirus disease 2019 pandemic: A survey study. J. Womens Health. 2022; 31: 84–90.

Li K, Chen G, Hou H. at all Analysis of sex hormones and menstruation in COVID-19 women of child-bearing age. Reprod Biomed Online. 2021 Jan; 42(1): 260-267

Orhan C, Çelenay ŞT, Demirtürk F. at all Effects of menstrual pain on the academic performance and participation in sports and social activities in Turkish university students with primary dysmenorrhea: A case control study. J Obstet Gynaecol Res. 2018 Nov; 44(11): 2101-2109.

Anwar MM, Badawi AM, Eltablawy NA. Can the coronavirus infection penetrate the brain resulting in sudden anosmia followed by severe neurological disorders? NeurologicalSci. 2020 Dec; 21: 100290.

Favieri F, Forte G, Agostini F. at all The Cognitive Consequences of the COVID-19 Pandemic on Members of the General Population in Italy: A Preliminary Study on Executive Inhibition. J Clin Med. 2021 Dec 29; 11(1): 170.

Takmaz T, Gundogmus I, Okten SB. at all. The impact of COVID-19-related mental health issues on menstrual cycle characteristics of female healthcare providers. J Obstet Gynaecol Res. 2021 Sep; 47(9): 3241-3249.

Bouchard TP, Schneider M, Schmidt M. at all. Menstrual Cycle Parameters Are Not Significantly Different After COVID-19 Vaccination. J Women’s Health (Larchmt). 2022 Aug;31(8):1097-1102.

Nagma S. To evaluate the effect of perceived stress on menstrual function. J. Clin. Diagn. Res. 2015; 9: QC01–QC03.

Nazir M, Asghar S, Rathore MA. at all. Menstrual abnormalities after COVID-19 vaccines: A systematic review. Vacunas. 2022 Sep-Dec; 23: S77-S87

Edelman A, Boniface ER, Benhar E. at all. Association Between Menstrual Cycle Length and Coronavirus Disease 2019 (COVID-19) Vaccination: A U.S. Cohort. Obstet Gynecol. 2022 Apr 1; 139(4): 481-489.

Downloads

Published

2023-07-04

Issue

Section

Articles

How to Cite

1.
Asanidze E, Kristesashvili J, Tchagiashvili N, Kakhniashvili T, Asanidze A. The impact of the Coronavirus (COVID-19) on the menstrual cycle and mental health of young Georgian women. MIMM. 2023;25(1). doi:10.56580/GEOMEDI22